I dunno, if done well, and I think I'd prefer a band of misfits to a band of rabid powerplayers. misfits lend themselves to more plots because you don't have to up the ante so much to keep up.

And people tend to ROLEPLAY misfits more, I find. Becuase the character CLEARLY isn't about the gnarly powers.

One character as a misfit can work... but it becomes very easy to shunt him off as comic relief or have him eclipsed by the other players. You end up with someone who is always in shade and not often involved.